
Treatment
Treatment on Mind and Margin: CBT, DBT, ACT, EMDR, psychodynamic and exposure.
Profiles

Treatment-resistant depression definitions may overlook social causes
Clinical definitions of treatment-resistant depression, centered on failed drug trials, are being critiqued for not aligning with depression's diverse social and psychological origins, potentially biasing care toward biological treatments.

Gut Microbiome Linked to Early Brain Ageing
A 2026 UCLA-led study of nearly 1,500 adults found that accelerated brain ageing, detectable via fMRI in young adults, correlates with poorer memory.

Neurostimulation Offers New Circuit-Based Treatment in Psychiatry
A scientific review details how brain stimulation techniques like TMS and DBS are shifting psychiatric treatment toward directly targeting dysfunctional brain circuits.

New Trial Revives Psychodynamic Therapy Debate
A 2026 German trial suggests a modified form of psychodynamic psychotherapy may benefit patients with schizophrenia.

Digital Strategy Doubles Heart Failure Drug Initiation
A digital strategy that identified and contacted heart failure patients not on guideline-recommended medication more than doubled treatment initiation.

Alnylam defends RNAi drugs after AstraZeneca's Wainua trial failure
Alnylam defends its heart disease RNAi drugs after AstraZeneca's Wainua failed a trial. The company says its drugs work even with stabilizer therapies.

Twice-Daily Radiation Boosts Lung Cancer QOL
A patient-reported outcomes analysis from the NRG-LU005 trial links twice-daily radiation for limited-stage small cell lung cancer to a better quality of life than once-daily treatment.

Eye Drops Restore Vision in Blind Mice
Light-activated eye drops restored vision in blind mice, offering a potential new treatment for degenerative blindness without gene therapy or implants.

New Clozapine Regulations May Widen Ethnic Disparities
Revised monitoring requirements for clozapine may inadvertently worsen existing inequalities in access to treatment for people of African ancestry.

Estrogen-Only Hormone Therapy Linked to Lower Alzheimer’s Risk in Older Women
A new retrospective study of more than 21,000 women finds that use of estrogen-only menopausal hormone therapy is associated with reduced Alzheimer’s pathology, lower odds of dementia diagnosis, and fewer memory-related symptoms, though the findings apply mainly to women who have had a hysterectomy and may not generalize to all hormone users.



